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Description for Protein ME2

malic enzyme 2, NAD(+)-dependent, mitochondrial
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/1)
(cAMP/cGMP binding: 1; microparticles: 1; platelet: 4; secretome: 1; undefined: 1)
Summary:
This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.1.1.38
KEGG - Orthology:
K00027
KEGG - Pathway(s):
hsa00620
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Malic enzyme NAD(+)-dependent mitochondrial; NAD-ME
Approved Symbol:
ME2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 0
No human (de-) phosphorylation sites; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alpha-Ketomalonic Acid(db);
  • Fumarate(db);
  • Malate Ion(db);
  • NADH(db);
  • Nicotinamide-Adenine-Dinucleotide(db);
  • Oxalate Ion(db);
  • Tartronate(db)

    Associated Genetic Diseases:

  • Epilepsy, idiopathic generalized, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01103 Entrez Gene ID: 4200 OMIM ID: 154270 Swissprot Accession: P23368; Q9BWL6;