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Description for Protein MDM2

Mdm2 p53 binding protein homolog (mouse)
101 total interacting proteins; 35 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • NES: Nuclear Export Signal
  • ZnF_RBZ: Zinc finger domain
  • RING: Ring finger
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    6.3.2.19
    KEGG - Orthology:
    K06643
    KEGG - Pathway(s):
    hsa04110; hsa04115; hsa04120; hsa04144; hsa05200; hsa05214; hsa05215; hsa05218; hsa05219; hsa05220
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    p53 binding protein Mdm2; HDM2; Ubiquitin protein ligase E3 Mdm2; Oncoprotein Mdm2; Double minute 2 homolog; MGC71221; Double minute 2, human homolog of; EC 6.3.2.-; Double minute 2 protein; Double minute 2 homolog isoform MDM2; Double minute 2 homolog isoform MDM2a; Double minute 2 homolog isoform MDM2b; Double minute 2 homolog isoform MDM2d; Double minute 2 homolog isoform MDM2e; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein; HDMX
    Approved Symbol:
    MDM2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 76
    Human (de-) phosphorylation sites: 76; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Cis-[4,5-Bis-(4-Bromophenyl)-2-(2-Ethoxy-4-Methoxyphenyl)-4,5-Dihydroimidazol-1-Yl]-[4-(2-Hydroxyethyl)Piperazin-1-Yl]Methanone(db);
  • Cis-[4,5-Bis-(4-Chlorophenyl)-2-(2-Isopropoxy-4-Methoxyphenyl)-4,5-Dihyd Roimidazol-1-Yl]-Piperazin-1-Yl-Methanone(db)

    Associated Genetic Diseases:

  • Accelerated tumor formation, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 9 : 0
  • Isoform 8 : 0
  • Isoform 7 : 0
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01272 Entrez Gene ID: 4193 OMIM ID: 164785 Swissprot Accession: Q00987; A7UKX8; A7UKX9;