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Description for Protein MDH2

malate dehydrogenase 2, NAD (mitochondrial)
7 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 7/1)
(microparticles: 1; platelet: 6; secretome: 1)
Summary:
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.1.1.37
KEGG - Orthology:
K00026
KEGG - Pathway(s):
hsa00020; hsa00620; hsa00630; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Malate dehydrogenase 2, NAD (mitochondrial); mMDH; MDH; MOR1
Approved Symbol:
MDH2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 5
Human (de-) phosphorylation sites: 5; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Citric Acid(db);
  • NADH(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01099 Entrez Gene ID: 4191 OMIM ID: 154100 Swissprot Accession: P40926;