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Description for Protein CD46

CD46 molecule, complement regulatory protein
14 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(membrane: 1; platelet: 7; undefined: 1)
Summary:
The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. The encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • SUSHI: Sushi domain (SCR repeat)
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04007
    KEGG - Pathway(s):
    hsa04610
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Membrane cofactor protein isoform 6; Membrane cofactor protein isoform 9; Membrane cofactor protein isoform 5; Membrane cofactor protein isoform 12; Membrane cofactor protein isoform 14; Membrane cofactor protein isoform 11; Membrane cofactor protein isoform 2; Membrane cofactor protein isoform 8; Membrane cofactor protein isoform 4; Membrane cofactor protein isoform 7; Membrane cofactor protein isoform 3; Membrane cofactor protein isoform 13; Membrane cofactor protein isoform 10; Membrane cofactor protein isoform 1; Complement membrane cofactor protein; Trophoblast leucocyte common antigen; Membrane cofactor protein; Measles virus receptor; TLX; MIC10; TRA2.10; MGC26544; CD46 antigen; Antigen identified by monoclonal antibody TRA-2-10
    Approved Symbol:
    CD46
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 24
    Human (de-) phosphorylation sites: 24; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alpha-D-Mannose(db)

    Associated Genetic Diseases:

  • Hemolytic-uremic syndrome, atypical(Pd)
    		• Predicted Transmembrane Domains:
    00406_14(1)
    00406_13(0)
    00406_12(1)
    00406_11(1)
    00406_10(1)
  • Isoform 9 : 1
  • Isoform 8 : 1
  • Isoform 7 : 0
  • Isoform 6 : 1
  • Isoform 5 : 1
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00406 Entrez Gene ID: 4179 OMIM ID: 120920 Swissprot Accession: P15529;