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Description for Protein MCM7

minichromosome maintenance complex component 7
54 total interacting proteins; 15 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • MCM: minichromosome maintenance proteins
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K02210
    KEGG - Pathway(s):
    hsa03030; hsa04110
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Minichromosome maintenance protein 7 isoform 2; Minichromosome maintenance protein 7 isoform 1; CDC47; P85MCM; P1CDC47; PNAS-146; CDABP0042; P1.1-MCM3; MCM7 minichromosome maintenance deficient 7; DNA replication licensing factor MCM7; Minichromosome maintenance protein 7
    Approved Symbol:
    MCM7
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 19
    Human (de-) phosphorylation sites: 19; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01154 Entrez Gene ID: 4176 OMIM ID: 600592 Swissprot Accession: A4D2A2; P33993;