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Description for Protein MCM3

minichromosome maintenance complex component 3
39 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetlyated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • AAA: ATPases associated with a variety of cellular activities
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K02541
    KEGG - Pathway(s):
    hsa03030; hsa04110
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Replication licensing factor beta subunit; P1 protein; DNA replication licensing factor MCM3; DNA polymerase alpha holoenzyme-associated protein P1; RLF beta subunit; P1-MCM3; MCM3 minichromosome maintenance deficient 3; RLFB; P102 protein; HCC5; MGC1157; P1.h; Cervical cancer proto-oncogene 5; hRlf beta subunit; minichromosome maintenance deficient; Minichromosome maintenance protein 3
    Approved Symbol:
    MCM3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 22
    Human (de-) phosphorylation sites: 22; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04072 Entrez Gene ID: 4172 OMIM ID: 602693 Swissprot Accession: P25205;