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Description for Protein MCM2

minichromosome maintenance complex component 2
53 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • MCM: minichromosome maintenance proteins
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K02540
    KEGG - Pathway(s):
    hsa03030; hsa04110
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Minichromosome maintenance protein 2; Nuclear protein BM28; DNA replication licensing factor MCM2; CDCL1; BM28; KIAA0030; Mitotin; Cell division cycle like 1; Cdc19; D3S3194
    Approved Symbol:
    MCM2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 26
    Human (de-) phosphorylation sites: 26; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 00303 Entrez Gene ID: 4171 OMIM ID: 116945 Swissprot Accession: P49736;