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Description for Protein MCL1

myeloid cell leukemia sequence 1 (BCL2-related)
31 total interacting proteins; 18 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • BCL: BCL (B-Cell lymphoma)
  • contains BH1, BH2 regions
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K02539
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Myeloid cell leukemia sequence 1 isoform 1; Myeloid cell leukemia sequence 1 isoform 2; Induced myeloid leukemia cell differentiation protein Mcl-1; Myeloid cell leukemia 1, long isoform; Myeloid cell leukemia 1, short isoform; TM; EAT; MGC1839; MGC104264; MCL1S; MCL1L
    Approved Symbol:
    MCL1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 08870 Entrez Gene ID: 4170 OMIM ID: 159552 Swissprot Accession: Q07820;