Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein MBL2

mannose-binding lectin (protein C) 2, soluble (opsonic defect)
9 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(secretome: 1)
Summary:
This gene encodes the soluble mannose-binding lectin or mannose-binding protein found in serum. The protein encoded belongs to the collectin family and is an important element in the innate immune system. The protein recognizes mannose and N-acetylglucosamine on many microorganisms, and is capable of activating the classical complement pathway. Deficiencies of this gene have been associated with susceptibility to autoimmune and infectious diseases. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • LECTIN_C: C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03991
    KEGG - Pathway(s):
    hsa04610
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MBL; Lectin mannose binding soluble 2; Mannose binding protein, serum; Mannose binding protein; MBP1; MBP; COLEC1
    Approved Symbol:
    MBL2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Alpha-D-Mannose(db);
  • Alpha-L-1-Methyl-Fucose(db);
  • Alpha-L-Methyl-Fucose(db);
  • Alpha-Methyl-N-Acetyl-D-Glucosamine(db);
  • Beta-L-Methyl-Fucose(db);
  • Beta-Methyl-D-Galactoside(db);
  • Fucose(db);
  • O-Sialic Acid(db);
  • O1-Methyl-Mannose(db);
  • O3-Sulfonylgalactose(db);
  • O4-Sulfonylgalactose(db)

    Associated Genetic Diseases:

  • Mannose-binding protein deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01107 Entrez Gene ID: 4153 OMIM ID: 154545 Swissprot Accession: P11226; Q5SQS3;