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Description for Protein MATK

megakaryocyte-associated tyrosine kinase
9 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene has amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain, a unique N terminus, lack of myristylation signals, lack of a negative regulatory phosphorylation site, and lack of an autophosphorylation site. This protein is thought to play a significant role in the signal transduction of hematopoietic cells. It is able to phosphorylate and inactivate Src family kinases, and may play an inhibitory role in the control of T-cell proliferation. This protein might be involved in signaling in some cases of breast cancer. Three alternatively spliced transcript variants that encode different isoforms have been described for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH2: Src homology 2 domains
  • Tyr_Kinase: tyrosine kinase domain
  • SH3: Src homology 3 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.2
    KEGG - Orthology:
    K08888
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Megakaryoctye-associated tyrosine kinase; Hematopoietic consensus tyrosine-lacking kinase; CSK-type protein tyrosine kinase; HYL; CTK; Tyrosine protein kinase CTK; Protein kinase HYL; CHK; Tyrosylprotein kinase; Hydroxyaryl protein kinase; Megakaryocyte-associated tyrosine kinase isoform b; Megakaryocyte-associated tyrosine kinase isoform c; Megakaryocyte-associated tyrosine kinase isoform a; Lsk; HYLTK; HHYLTK; MGC1708; MGC2101; DKFZp434N1212; HYL tyrosine kinase; Tyrosine kinase MATK; Leukocyte carboxyl-terminal src kinase related gene; EC 2.7.10.2
    Approved Symbol:
    MATK
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 1
    Human phosphorylation targets: 1; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02496 Entrez Gene ID: 4145 OMIM ID: 600038 Swissprot Accession: P42679; B3KNZ9; Q9NST8;