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Description for Protein MAPT

microtubule-associated protein tau
73 total interacting proteins; 49 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K04380
KEGG - Pathway(s):
hsa04010; hsa05010
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Microtubule associated protein tau isoform 2; Microtubule associated protein tau isoform 3; Microtubule associated protein tau isoform 4; Microtubule-associated protein tau isoform 1; MTBT1; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; Tau
Approved Symbol:
MAPT
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 335
Human (de-) phosphorylation sites: 335; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

  • Dementia, frontotemporal(Pd);
  • Dementia, frontotemporal, with parkinsonism(Pd);
  • Pick disease(Pd);
  • Supranuclear palsy, progressive(Pd);
  • Supranuclear palsy, progressive atypical(Pd);
  • Tauopathy and respiratory failure(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 6 : 0
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01142 Entrez Gene ID: 4137 OMIM ID: 157140 Swissprot Accession: P10636;