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Description for Protein MAOB

monoamine oxidase B
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 6/1)
(membrane: 2; microparticles: 1; platelet: 3; undefined: 1)
Summary:
The protein encoded by this gene belongs to the flavin monoamine oxidase family. It is a enzyme located in the mitochondrial outer membrane. It catalyzes the oxidative deamination of biogenic and xenobiotic amines and plays an important role in the metabolism of neuroactive and vasoactive amines in the central nervous sysytem and peripheral tissues. This protein preferentially degrades benzylamine and phenylethylamine. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    1.4.3.4
    KEGG - Orthology:
    K00274
    KEGG - Pathway(s):
    hsa00260; hsa00330; hsa00340; hsa00350; hsa00360; hsa00380; hsa00982; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    MAO, Platelet; MAO, Brain; Amine oxidase [flavin-containing] B; Monoamine oxidase; Tyramine oxidase; Adrenalin oxidase
    Approved Symbol:
    MAOB
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (1Z)-4-(4-FLUOROPHENYL)-2-METHYLIDENEBUTAN-1-IMINE(db);
  • (S)-(+)-2-[4-(FLUOROBENZYLOXY-BENZYLAMINO)PROPIONAMIDE](db);
  • 4-HYDROXY-N-PROPARGYL-1(R)-AMINOINDAN(db);
  • 4-Methoxyamphetamine(db);
  • 5-Hydroxy-N-Propargyl-1(R)-Aminoindan(db);
  • 7-[(3-CHLOROBENZYL)OXY]-2-OXO-2H-CHROMENE-4-CARBALDEHYDE(db);
  • 7-[(3-CHLOROBENZYL)OXY]-4-[(METHYLAMINO)METHYL]-2H-CHROMEN-2-ONE(db);
  • Ephedra(db);
  • Farnesol(db);
  • Flavin-Adenine Dinucleotide(db);
  • Isatin(db);
  • Isocarboxazid(db);
  • Lauryl Dimethylamine-N-Oxide(db);
  • Methamphetamine(db);
  • MMDA(db);
  • N-(2-AMINOETHYL)-P-CHLOROBENZAMIDE(db);
  • N-Dodecyl-N,N-Dimethyl-3-Ammonio-1-Propanesulfonate(db);
  • N-Methyl-N-Propargyl-1(R)-Aminoindan(db);
  • N-METHYL-N-[(1R)-1-METHYL-2-PHENYLETHYL]PROP-2-EN-1-AMINE(db);
  • N-Propargyl-1(S)-Aminoindan(db);
  • Pargyline(db);
  • Phenelzine(db);
  • Phentermine(db);
  • Rasagiline(db);
  • Selegiline(db);
  • Tranylcypromine(db);
  • Zonisamide(db);
  • [(1e)-4-Phenylbut-1-Enyl]Benzene(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 02401 Entrez Gene ID: 4129 OMIM ID: 309860 Swissprot Accession: P27338;