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Description for Protein MAOA

monoamine oxidase A
4 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; platelet: 1)
Summary:
This gene encodes monoamine oxidase A, an enzyme that degrades amine neurotransmitters, such as dopamine, norepinephrine, and serotonin. The protein localizes to the mitochondrial outer membrane. The gene is adjacent to a related gene on the opposite strand of chromosome X. Mutation in this gene results in monoamine oxidase deficiency, or Brunner syndrome. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.4.3.4
KEGG - Orthology:
K00274
KEGG - Pathway(s):
hsa00260; hsa00330; hsa00340; hsa00350; hsa00360; hsa00380; hsa00982; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
MAO-A
Approved Symbol:
MAOA
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 4-Methoxyamphetamine(db);
  • 7-METHOXY-1-METHYL-9H-BETA-CARBOLINE(db);
  • DECYL(DIMETHYL)PHOSPHINE OXIDE(db);
  • Ephedra(db);
  • Flavin-Adenine Dinucleotide(db);
  • Isocarboxazid(db);
  • Methamphetamine(db);
  • Minaprine(db);
  • MMDA(db);
  • Moclobemide(db);
  • N-Methyl-N-Propargyl-3-(2,4-Dichlorophenoxy)Propylamine(db);
  • Pargyline(db);
  • Phenelzine(db);
  • Phentermine(db);
  • Selegiline(db);
  • Tranylcypromine(db);
  • Zonisamide(db)

    Associated Genetic Diseases:

  • Antisocial behavior following childhood maltreatment, susceptibility to(Pd);
  • Brunner syndrome(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02400 Entrez Gene ID: 4128 OMIM ID: 309850 Swissprot Accession: Q53YE7; P21397;