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Description for Protein MAN2A1

mannosidase, alpha, class 2A, member 1
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(alpha granules: 1; membrane: 1; secretome: 1)
Summary:
This gene encodes a protein which is a member of family 38 of the glycosyl hydrolases. The protein is located in the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.2.1.114
    KEGG - Orthology:
    K01231
    KEGG - Pathway(s):
    hsa00510; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Mannosidase alpha II; MANA2; Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase; Golgi alpha-mannosidase II; MAN II; GlcNAc transferase I-dependent alpha 1,3[alpha 1,6] mannosidase
    Approved Symbol:
    MAN2A1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (1R,2R,3R,4S,5R)-4-(BENZYLAMINO)-5-(METHYLTHIO)CYCLOPENTANE-1,2,3-TRIOL(db);
  • (1S,2S,3R,6R)-4-(hydroxymethyl)-6-(octylamino)cyclohex-4-ene-1,2,3-triol(db);
  • 1,5-Dideoxy-1,5-Imino-D-Mannitol(db);
  • 2-Deoxy-2-Fluoro-Alpha-D-Mannosyl Fluoride(db);
  • 2-Methyl-2,4-Pentanediol(db);
  • 5-Fluoro-Beta-L-Gulosyl Fluoride(db);
  • 5-Thio-a/B-D-Mannopyranosylamine(db);
  • Ghavamiol(db);
  • Kifunensine(db);
  • Swainsonine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01110 Entrez Gene ID: 4124 OMIM ID: 154582 Swissprot Accession: Q16706; Q49A69;