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Description for Protein MAL

mal, T-cell differentiation protein
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene is a highly hydrophobic integral membrane protein belonging to the MAL family of proteolipids. The protein has been localized to the endoplasmic reticulum of T-cells and is a candidate linker protein in T-cell signal transduction. In addition, this proteolipid is localized in compact myelin of cells in the nervous system and has been implicated in myelin biogenesis and/or function. The protein plays a role in the formation, stabilization and maintenance of glycosphingolipid-enriched membrane microdomains. Alternative splicing produces four transcript variants which vary from each other by the presence or absence of alternatively spliced exons 2 and 3. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    T-Lymphocyte maturation associated protein; Mal T-cell differentiation protein; T-cell differentiation protein MAL; T-lymphocyte maturation-associated protein isoform b; T-lymphocyte maturation-associated protein isoform c; T-lymphocyte maturation-associated protein isoform a; T-lymphocyte maturation-associated protein isoform d
    Approved Symbol:
    MAL
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 1
  • Isoform 3 : 3
  • Isoform 2 : 3
  • Isoform 1 : 4
    • Additional Identifiers:

    HPRD: 01789 Entrez Gene ID: 4118 OMIM ID: 188860 Swissprot Accession: P21145; Q6FH77;