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Description for Protein MAF

v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)
15 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a DNA-binding, leucine zipper-containing transcription factor that acts as a homodimer or as a heterodimer. Depending on the binding site and binding partner, the encoded protein can be a transcriptional activator or repressor. This protein plays a role in the regulation of several cellular processes, including embryonic lens fiber cell development, increased T-cell susceptibility to apoptosis, and chondrocyte terminal differentiation. Defects in this gene are a cause of juvenile-onset pulverulent cataract as well as congenital cerulean cataract 4 (CCA4). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • BRLZ: basic region leucin zipper
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09035
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Transcription factor Maf; Protooncogene c-maf; MGC71685; c-maf proto-oncogene; T lymphocyte c-maf long form; v-maf musculoaponeurotic fibrosarcoma oncogene homolog isoform a; v-maf musculoaponeurotic fibrosarcoma oncogene homolog isoform b; Musculoaponeurotic fibrosarcoma (MAF) protooncogene
    Approved Symbol:
    MAF
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Cataract, congenital, Cerulean type, 4(Pd);
  • Cataract, pulverulent, juvenile-onset(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01518 Entrez Gene ID: 4094 OMIM ID: 177075 Swissprot Accession: O75444;