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Description for Protein SMAD3

SMAD family member 3
210 total interacting proteins; 71 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 2)
Summary:
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K04500
KEGG - Pathway(s):
hsa04110; hsa04144; hsa04310; hsa04350; hsa04520; hsa05142; hsa05200; hsa05210; hsa05212; hsa05220
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
SMA and MAD related protein 3; JV15-2; HSMAD3; MADH3; Smad 3; HSPC193; HsT17436; MGC60396; DKFZP586N0721; DKFZp686J10186; Mothers against decapentaplegic homolog 3; Mad homolog JV15-2; Mad protein homolog; SMAD, mothers against DPP homolog 3; MAD, mothers against decapentaplegic homolog 3; Mothers against DPP homolog 3; Mad3; hMAD-3; hSMAD3
Approved Symbol:
SMAD3
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 36
Human (de-) phosphorylation sites: 36; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

None Available

Associated Genetic Diseases:

None Available
Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04380 Entrez Gene ID: 4088 OMIM ID: 603109 Swissprot Accession: B7Z4Z5; Q9P0T0; P84022;