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Description for Protein SMAD2

SMAD family member 2
187 total interacting proteins; 64 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(platelet: 3; secretome: 1)
Summary:
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation of this protein into the nucleus, where it binds to target promoters and forms a transcription repressor complex with other cofactors. This protein can also be phosphorylated by activin type 1 receptor kinase, and mediates the signal from the activin. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
None Available
KEGG - Orthology:
K04500
KEGG - Pathway(s):
hsa04110; hsa04144; hsa04310; hsa04350; hsa04520; hsa05142; hsa05200; hsa05210; hsa05212
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Sma- and Mad-related protein 2; MADH2; MADR2; JV18; JV18-1; MGC22139; MGC34440; hMAD-2; hSMAD2; Mad protein homolog; MAD, mothers against decapentaplegic homolog 2; Mad-related protein 2; Mother against DPP homolog 2; SMAD family member 2; SMAD, mothers against DPP homolog 2; Mad, mothers against decapentaplegic homolog 2
Approved Symbol:
SMAD2
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 25
Human (de-) phosphorylation sites: 25; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Phosphonoserine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03221 Entrez Gene ID: 4087 OMIM ID: 601366 Swissprot Accession: Q15796; Q53XR6;