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Description for Protein LYZ

lysozyme
10 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(alpha granules: 1; secretome: 1)
Summary:
This gene encodes human lysozyme, whose natural substrate is the bacterial cell wall peptidoglycan (cleaving the beta[1-4]glycosidic linkages between N-acetylmuramic acid and N-acetylglucosamine). Lysozyme is one of the anti-microbial agents found in human milk, and is also present in spleen, lung, kidney, white blood cells, plasma, saliva, and tears. Missense mutations in LYZ have been identified in heritable renal amyloidosis. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.2.1.17
    KEGG - Orthology:
    K13915
    KEGG - Pathway(s):
    hsa04970
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    -
    Approved Symbol:
    LYZ
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-Proponol(db);
  • 2,3-Propandiol(db);
  • 2-Methyl-2,4-Pentanediol(db);
  • 3-Aminosuccinimide(db);
  • 4-Aminophenylarsonic Acid(db);
  • 4-Methylumbelliferyl Chitobiose(db);
  • Acetate Ion(db);
  • Alpha-D-Mannose(db);
  • Chitotriose(db);
  • Cu-Bicyclam(db);
  • Cu-Cyclam(db);
  • Di(N-Acetyl-D-Glucosamine)(db);
  • Dodecyl Sulfate(db);
  • L-Aspartic Acid(db);
  • Methylumbelliferyl Chitotriose(db);
  • Para-Toluene Sulfonate(db);
  • Sucrose(db);
  • Terminal Dimethyl(db);
  • UNDECA-3,7-DIENE-1,3,7,11-TETRACARBALDEHYDE(db)

    Associated Genetic Diseases:

  • Amyloidosis, familial visceral(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01085 Entrez Gene ID: 4069 OMIM ID: 153450 Swissprot Accession: P61626; B2R4C5;