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Description for Protein LYN

v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
112 total interacting proteins; 60 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 7/2)
(membrane: 2; microparticles: 1; phosphoproteome: 1; platelet: 3; secretome: 2; undefined: 2)
Summary:
(PubMed Links)
Domains and Motifs:
  • SH2: Src homology 2 domains
  • Tyr_Kinase: tyrosine kinase domain
  • SH3: Src homology 3 domains
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.2
    KEGG - Orthology:
    K05854
    KEGG - Pathway(s):
    hsa04062; hsa04662; hsa04664; hsa04666; hsa04730; hsa05120
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Oncogene LYN; Tyrosine-protein kinase Lyn; EC 2.7.10.2; JTK8; FLJ26625
    Approved Symbol:
    LYN
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 40
    Human (de-) phosphorylation sites: 40; Platelet phosphorylation sites: 1
    Phosphorylation Targets:
    Total phosphorylation targets: 35
    Human phosphorylation targets: 34; Predicted platelet targets: 1
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 1-Tert-Butyl-3-(4-Chloro-Phenyl)-1h-Pyrazolo[3,4-D]Pyrimidin-4-Ylamine(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01301 Entrez Gene ID: 4067 OMIM ID: 165120 Swissprot Accession: P07948; Q6NUK7;