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Description for Protein ARNTL

aryl hydrocarbon receptor nuclear translocator-like
21 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This complex binds an E-box upstream of the PER1 gene, activating this gene and possibly other circadian rhythym-associated genes. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PAS: PAS domain
  • PAC: Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)
  • HLH: helix loop helix domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K02296
    KEGG - Pathway(s):
    hsa04710
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    BMAL1; Member of PAS superfamily 3; MOP3; Brain and muscle ARNT like 1; Member of PAS protein 3; Basic helix loop helix PAS orphan MOP3; bHLH PAS protein JAP3; JAP3; MGC47515; BMAL1c; PASD3; TIC; ARNT-like protein 1 brain and muscle; Aryl hydrocarbon receptor nuclear translocator-like isoform a; Aryl hydrocarbon receptor nuclear translocator-like isoform b
    Approved Symbol:
    ARNTL
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03973 Entrez Gene ID: 406 OMIM ID: 602550 Swissprot Accession: O00327; A2I2N6;