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Description for Protein BCAM

basal cell adhesion molecule (Lutheran blood group)
5 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Lutheran blood group glycoprotein is a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five, N-terminus, extracellular immunoglobulin domains, a single transmembrane domain, and a short, C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • IGC2: Immunoglobulin C-2 Type
  • IG: Immunoglobulin
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06578
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Blood group lutheran system; BCAM; Lutheran blood group glycoprotein isoform 2 precursor; Lutheran blood group glycoprotein isoform 1 precursor; Lutheran blood group glycoprotein; F8/G253 antigen; Auberger b antigen; B-CAM cell surface glycoprotein; Antigen identified by monoclonal antibody F8; B-cell adhesion molecule; Glycoprotein 95kDa; MSK19; AU
    Approved Symbol:
    BCAM
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Auberger blood group polymorphism AU(A)/AU(B)(Pd);
  • Lutheran blood group polymorphism LU(A)/LU(B)(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00197 Entrez Gene ID: 4059 OMIM ID: 612773 Swissprot Accession: P50895;