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Description for Protein LTC4S

leukotriene C4 synthase
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/1)
(membrane: 1; undefined: 2)
Summary:
The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
4.4.1.20
KEGG - Orthology:
K00807
KEGG - Pathway(s):
hsa00590; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
LTC4 synthase; Leukotriene-C(4)synthase; LTCS; EC 4.4.1.20; MGC33147; Leukotriene C4 synthase isoform 1
Approved Symbol:
LTC4S
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 1
Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Glutathione(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 1
  • Isoform 1 : 3
    • Additional Identifiers:

    HPRD: 02004 Entrez Gene ID: 4056 OMIM ID: 246530 Swissprot Accession: Q16873;