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Description for Protein LTBR

lymphotoxin beta receptor (TNFR superfamily, member 3)
13 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein specifically binds the lymphotoxin membrane form (a complex of lymphotoxin-alpha and lymphtoxin-beta). The encoded protein and its ligand play a role in the development and organization of lymphoid tissue and tranformed cells. Activation of the encoded protein can trigger apoptosis. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TNFR: Tumor necrosis factor receptor / nerve growth factor receptor repeats.
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K03159
    KEGG - Pathway(s):
    hsa04060; hsa04672
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Lymphotoxin beta receptor; LT beta R; Tumor necrosis factor C receptor; TNFCR; Tumor necrosis factor receptor superfamily member 3; Tumor necrosis factor receptor 2 related protein; TNFRSF3
    Approved Symbol:
    LTBR
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 02988 Entrez Gene ID: 4055 OMIM ID: 600979 Swissprot Accession: P36941;