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Description for Protein LTBP1

latent transforming growth factor beta binding protein 1
9 total interacting proteins; 5 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 8/2)
(alpha granules: 2; membrane: 2; microparticles: 1; platelet: 5; secretome: 2; undefined: 2)
Summary:
The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • EGFCA: Calcium-binding EGF-like domain
  • EGF: Epidermal growth factor-like domain.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K08023
    KEGG - Pathway(s):
    hsa04350
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Latent transforming growth factor beta binding protein 1 isoform LTBP1S; Latent transforming growth factor beta binding protein 1 isoform LTBP1L; Transfoming growth factor beta 1 binding protein; TGF beta 1 binding protein; TGF beta1 BP-1; Latent transforming growth factor beta binding protein
    Approved Symbol:
    LTBP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 20
    Human (de-) phosphorylation sites: 20; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01039 Entrez Gene ID: 4052 OMIM ID: 150390 Swissprot Accession: Q14766; B7ZLY3;