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Description for Protein LTA

lymphotoxin alpha (TNF superfamily, member 1)
10 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The encoded protein, a member of the tumor necrosis factor family, is a cytokine produced by lymphocytes. The protein is highly inducible, secreted, and forms heterotrimers with lymphotoxin-beta which anchor lymphotoxin-alpha to the cell surface. This protein also mediates a large variety of inflammatory, immunostimulatory, and antiviral responses, is involved in the formation of secondary lymphoid organs during development and plays a role in apoptosis. Genetic variations in this gene are associated with susceptibility to leprosy type 4 and psoriatic arthritis. (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TNF: Tumour necrosis factor family.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K05468
    KEGG - Pathway(s):
    hsa04060; hsa04612; hsa04940
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    TNF superfamily, member 1; Lymphotoxin alpha; Lymphotoxin; Lymphotoxin A; Lyphotoxin alpha; LT-alpha; LT; TNFB; TNFSF1; TNF, lymphocyte derived; Tumor necrosis factor ligand superfamily member 1; Tumor necrosis factor beta
    Approved Symbol:
    LTA
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Etanercept(db)

    Associated Genetic Diseases:

  • LTA protein production, modulator of(Pd);
  • Myocardial infarction, susceptibility to(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01084 Entrez Gene ID: 4049 OMIM ID: 153440 Swissprot Accession: P01374; Q5STV3;