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Description for Protein LRP1

low density lipoprotein receptor-related protein 1
61 total interacting proteins; 32 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
The protein encoded by this gene is an endocytic receptor involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the A2M-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer patients. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • LDLA: Low-density lipoprotein receptor domain class A
  • EGFL: EGF domain, unclasssified subfamily
  • EGF: Epidermal growth factor-like domain.
  • EGFCA: Calcium-binding EGF-like domain
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04550
    KEGG - Pathway(s):
    hsa05010; hsa05144
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Lipoprotein receptor-related protein; Alpha-2 macroglobulin receptor; Apolipoprotein receptor; Apolipoprotein E receptor; Alpha-2 MRA; APOER; RAP; CD91; A2MR; LRP; APR
    Approved Symbol:
    LRP1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Antihemophilic Factor(db);
  • Coagulation Factor IX(db);
  • Tenecteplase(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 00138 Entrez Gene ID: 4035 OMIM ID: 107770 Swissprot Accession: Q07954; Q59FG2;