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Description for Protein LMX1A

LIM homeobox transcription factor 1, alpha
6 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene (INS; MIM 176730) and interact with RNA polymerase to activate or repress transcription. LMX1 is a homeodomain protein that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin (German et al., 1994 [PubMed 7698771]).[supplied by OMIM] (PubMed Links)
Domains and Motifs:
  • HOX: Homeodomain
  • LIM: Zinc-binding domain present in Lin-11, Isl-1, Mec-3.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K09371
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Lim homeo box transcription factor 1; LMX1; LMX1.1; Insulin regulating transcription factor LMX1; LIM/homeobox protein LMX1A; LIM homeobox protein 1.1; MGC87616; LIM homeobox transcription factor 1, alpha isoform a; LIM homeobox transcription factor 1, alpha isoform b; LIM homeobox transcription factor 1, alpha isoform c
    Approved Symbol:
    LMX1A
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02623 Entrez Gene ID: 4009 OMIM ID: 600298 Swissprot Accession: Q8TE12; Q6NZ39;