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Description for Protein ACCN1

amiloride-sensitive cation channel 1, neuronal
5 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this gene may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium. Alternative splicing has been observed at this locus and two variants, encoding distinct isoforms, have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04828
    KEGG - Pathway(s):
    hsa04742
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Amiloride-sensitive cation channel 1, neuronal (degenerin) isoform 1; Amiloride-sensitive cation channel 1, neuronal (degenerin) isoform 2; Amiloride sensitive cation channel neuronal 1; Brain sodium channel 1; BNAC1; Sodium channel nonvoltage gated neuronal 1; Mammalian degenerin; MDEG; ACCN; ASIC2; ASIC2a; Degenerin channel MDEG
    Approved Symbol:
    ACCN1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Amiloride(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03471 Entrez Gene ID: 40 OMIM ID: 601784 Swissprot Accession: Q16515;