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Description for Protein LIPC

lipase, hepatic
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • LH2: Lipoxygenase homology 2 (beta barrel) domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.1.1.3
    KEGG - Orthology:
    K01046
    KEGG - Pathway(s):
    hsa00561; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    LIPH; Hepatic triglyceride lipase; HTGL; HL
    Approved Symbol:
    LIPC
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 1
    Human (de-) phosphorylation sites: 1; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Diabetes mellitus, noninsulin-dependent, susceptibility to(Pd);
  • Hepatic lipase deficiency(Pd);
  • Serum hdl cholesterol level, modifier of(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01058 Entrez Gene ID: 3990 OMIM ID: 151670 Swissprot Accession: A6H8L5; P11150;