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Description for Protein LIMK1

LIM domain kinase 1
25 total interacting proteins; 14 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 2)
Summary:
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • PDZ: Domain present in PSD-95, Dlg, and ZO-1/2.
  • LIM: Zinc-binding domain present in Lin-11, Isl-1, Mec-3.
  • S_T_kinase: Serine/Threonine protein kinases, catalytic domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.11.1
    KEGG - Orthology:
    K05743
    KEGG - Pathway(s):
    hsa04360; hsa04666; hsa04810
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    LIMK; LIM kinase; LIM motif containing protein kinase; EC 2.7.1.37; LIM domain kinase 1 isoform 1
    Approved Symbol:
    LIMK1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 19
    Human (de-) phosphorylation sites: 19; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 4
    Human phosphorylation targets: 4; Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03210 Entrez Gene ID: 3984 OMIM ID: 601329 Swissprot Accession: P53667;