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Description for Protein ABLIM1

actin binding LIM protein 1
15 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/2)
(phosphoproteome: 1; platelet: 18; undefined: 1)
Summary:
This gene encodes a cytoskeletal LIM protein that binds to actin filaments via a domain that is homologous to erythrocyte dematin. LIM domains, found in over 60 proteins, play key roles in the regulation of developmental pathways. LIM domains also function as protein-binding interfaces, mediating specific protein-protein interactions. The protein encoded by this gene could mediate such interactions between actin filaments and cytoplasmic targets. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • LIM: Zinc-binding domain present in Lin-11, Isl-1, Mec-3.
  • CC: Coiled Coil
  • VHP: Villin headpiece domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07520
    KEGG - Pathway(s):
    hsa04360
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    LIMAB1; LIMATIN; ABLIM; LIM actin binding protein 1; FLJ14564; KIAA0059; Actin binding double zinc finger protein; Actin binding LIM protein 1 isoform a; Actin binding LIM protein 1 isoform c; Actin binding LIM protein 1 isoform s; MGC1224; Actin binding LIM protein 1 isoform b
    Approved Symbol:
    ABLIM1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 150
    Human (de-) phosphorylation sites: 150; Platelet phosphorylation sites: 4
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 03819 Entrez Gene ID: 3983 OMIM ID: 602330 Swissprot Accession: Q5JVV2; O14639; B3KSG3;