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Description for Protein LHCGR

luteinizing hormone/choriogonadotropin receptor
12 total interacting proteins; 6 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • LRR: Leucine-rich repeats, outliers
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K04248
    KEGG - Pathway(s):
    hsa04020; hsa04080
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    LCGR gonadotropin receptor; Lutropin choriogonadotropin receptor; LCGR; Gonadotropin receptor; Lutropin choriogonadotropic hormone receptor; Luteinizing hormone receptor; LSH-R; LH/CG-R
    Approved Symbol:
    LHCGR
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 0
    No human (de-) phosphorylation sites; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Buserelin(db);
  • Cetrorelix(db);
  • Choriogonadotropin alfa(db);
  • Goserelin(db);
  • Lutropin alfa(db);
  • Menotropins(db)

    Associated Genetic Diseases:

  • Hypogonadotropic hypogonadism with micropenis(Pd);
  • Leydig cell adenoma, somatic, with male-limited precocious puberty(Pd);
  • Leydig cell hypoplasia(Pd);
  • Leydig cell hypoplasia with male pseudohermaphroditism(Pd);
  • Leydig cell hypoplasia, type II(Pd);
  • Luteinizing hormone/choriogonadotropin receptor, lq variant(Pd);
  • Micropenis(Pd);
  • Precocious puberty, male-limited(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 7
    • Additional Identifiers:

    HPRD: 01073 Entrez Gene ID: 3973 OMIM ID: 152790 Swissprot Accession: P22888;