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Description for Protein LGALS3

lectin, galactoside-binding, soluble, 3
17 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(membrane: 1)
Summary:
This gene encodes a member of the galectin family of carbohydrate binding proteins. Members of this protein family have an affinity for beta-galactosides. The encoded protein is characterized by an N-terminal proline-rich tandem repeat domain and a single C-terminal carbohydrate recognition domain. This protein can self-associate through the N-terminal domain allowing it to bind to multivalent saccharide ligands. This protein localizes to the extracellular matrix, the cytoplasm and the nucleus. This protein plays a role in numerous cellular functions including apoptosis, innate immunity, cell adhesion and T-cell regulation. Alternate splicing results in multiple transcript variants. (PubMed Links)
Domains and Motifs:
  • GLECT: Galectin
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06831
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Lectin, galactose binding soluble 3; Macrophage galactose specific lectin; MAC2; Galactoside binding protein; GALBP; Galectine 3; GAL3; Galactose specific lectin 3; MAC-2 antigen; IgE binding protein; 35 kDa lectin; Carbohydrate binding protein 35; CBP 35; Laminin-binding protein; Lectin L-29; L-31
    Approved Symbol:
    LGALS3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2,3,5,6-Tetrafluoro-4-Methoxy-Benzamide(db)

    Associated Genetic Diseases:

    None Available
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01090 Entrez Gene ID: 3958 OMIM ID: 153619 Swissprot Accession: P17931;