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Description for Protein ARHGAP6

Rho GTPase activating protein 6
No Interacting Proteins
Icon Book Platelet Evidence (proteome studies/others : 4/1)
(phosphoproteome: 1; platelet: 9; undefined: 1)
Summary:
This gene encodes a member of the rhoGAP family of proteins which play a role in the regulation of actin polymerization at the plasma membrane during several cellular processes. This protein is thought to have two independent functions, one as a GTPase-activating protein with specificity for RhoA, and another as a cytoskeletal protein that promotes actin remodeling. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SH3: Src homology 3 domains
  • RHOGAP: GTPase-activator protein for Rho-like GTPases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    RHO GTPase activating protein 6; Rho type GTPase activating protein RhoGAPX 1; GTPase activating protein RHO 6; Rho GTPase activating protein 6 isoform 1; Rho GTPase activating protein 6 isoform 2; Rho GTPase activating protein 6 isoform 3; Rho GTPase activating protein 6 isoform 5; Rho GTPase activating protein 6 isoform 4
    Approved Symbol:
    ARHGAP6
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 25
    Human (de-) phosphorylation sites: 25; Platelet phosphorylation sites: 17
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 5 : 0
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02124 Entrez Gene ID: 395 OMIM ID: 300118 Swissprot Accession: O43182; Q59HG6;