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Description for Protein LDHB

lactate dehydrogenase B
2 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 11/1)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 7; secretome: 2)
Summary:
This gene encodes an enzyme which catalyzes the reversible conversion of lactate and pyruvate, and NAD and NADH, in the glycolytic pathway. Mutations in this gene are associated with lactate dehydrogenase B deficiency. Pseudogenes have been identified on the X chromosome and on chromosome. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.1.1.27
KEGG - Orthology:
K00016
KEGG - Pathway(s):
hsa00010; hsa00270; hsa00620; hsa00640; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
LDH subunit H; LDH heart subunit; LDH H; LDH B
Approved Symbol:
LDHB
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 4
Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid(db);
  • NADH(db);
  • Nicotinamide-Adenine-Dinucleotide(db);
  • Oxamic Acid(db)

    Associated Genetic Diseases:

  • Lactate dehydrogenase-B deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01026 Entrez Gene ID: 3945 OMIM ID: 150100 Swissprot Accession: P07195; Q5U077;