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Description for Protein ARHGAP5

Rho GTPase activating protein 5
11 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/1)
(platelet: 1)
Summary:
Rho GTPase activating protein 5 negatively regulates RHO GTPases, a family which may mediate cytoskeleton changes by stimulating the hydrolysis of bound GTP. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RHOGAP: GTPase-activator protein for Rho-like GTPases
  • FF: Contains two conserved F residues
  • Small_GTPase: Small GTPase of the Ras superfamily
  • ill-defined subfamily
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K13709
    KEGG - Pathway(s):
    hsa04510; hsa04670
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    RHO GTPase activating protein 5; GTPase activating protein RHO 5; p190 B; p105 RhoGAP; Rho GTPase activating protein; p100 RasGAP associated p105 protein; Rho GTPase activating protein 5 isoform a; Rho GTPase activating protein 5 isoform b
    Approved Symbol:
    ARHGAP5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 23
    Human (de-) phosphorylation sites: 23; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04060 Entrez Gene ID: 394 OMIM ID: 602680 Swissprot Accession: Q13017;