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Description for Protein LDHA

lactate dehydrogenase A
8 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 11/0)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 7; secretome: 1)
Summary:
The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available
Gene Ontology:
Gene Ontology Annotations
KEGG - Enzyme ID(s):
1.1.1.27
KEGG - Orthology:
K00016
KEGG - Pathway(s):
hsa00010; hsa00270; hsa00620; hsa00640; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
LDH subunit M; L lactate dehydrogenase A chain; LDH muscle subunit; LDHM; PIG19; LDH1; Proliferation inducing gene 19 protein
Approved Symbol:
LDHA
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 8
Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • Acetate Ion(db);
  • Etheno-Nad(db);
  • NADH(db);
  • Nicotinamide(db);
  • Nicotinamide-Adenine-Dinucleotide(db);
  • Oxamic Acid(db)

    Associated Genetic Diseases:

  • Lactate dehydrogenase-A deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01025 Entrez Gene ID: 3939 OMIM ID: 150000 Swissprot Accession: B7Z5E3; P00338; B4DKQ2;