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Description for Protein LCT

lactase
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
The protein encoded by this gene belongs to the family 1 of glycosyl hydrolases. The protein is integral to plasma membrane and has both phlorizin hydrolase activity and lactase activity. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    3.2.1.108; 3.2.1.62
    KEGG - Orthology:
    K01229
    KEGG - Pathway(s):
    hsa00052
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    LAC; Lactase-phlorizin hydrolase; LPH; Lactase-glycosylceramidase; Phlorizin hydrolase
    Approved Symbol:
    LCT
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 3
    Human (de-) phosphorylation sites: 3; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • (1S,2S,3R,4S,5S)-2,3,4-TRIHYDROXY-5-(HYDROXYMETHYL)CYCLOHEXYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATE(db);
  • 2-Deoxy-2fluoro-Glucose(db);
  • 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL(db);
  • Alpha-D-Mannose(db);
  • D-Gluconhydroximo-1,5-Lactam(db);
  • ETHYL (1E)-2-PHENYL-N-(SULFOOXY)ETHANIMIDOTHIOATE(db);
  • Fucose(db);
  • Gluconolactone(db);
  • Nojirimycine Tetrazole(db);
  • Vitamin C(db);
  • Xylopyranose(db)

    Associated Genetic Diseases:

  • Lactase deficiency, congenital(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 04437 Entrez Gene ID: 3938 OMIM ID: 603202 Swissprot Accession: Q4ZG58; P09848;