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Description for Protein LAMA3

laminin, alpha 3
7 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Laminins are basement membrane components thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. The protein encoded by this gene is the alpha-3 subunit of laminin 5, which is a complex glycoprotein composed of three subunits (alpha, beta, and gamma). Laminin 5 is thought to be involved in cell adhesion, signal transduction and differentiation of keratinocytes. Mutations in this gene have been identified as the cause of Herlitz type junctional epidermolysis bullosa. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • LAMG: Laminin G domain
  • EGFLAM: Laminin-type epidermal growth factor-like domain
  • CC: Coiled Coil
  • LAMB: Laminin B domain
  • LAMNT: Laminin N-terminal domain (domain VI)
  • TSPN: Thrombospondin N-terminal -like domains.
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06240
    KEGG - Pathway(s):
    hsa04510; hsa04512; hsa05200; hsa05222
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Laminin A3; Laminin alpha 3 chain; Epiligrin 170 kD subunit; Laminin 5 alpha3 chain; Epiligrin alpha 3 subunit; Nicein 150kD subunit; Kalinin 165kD subunit; BM600 150kD subunit; Laminin alpha 3 subunit isoform 1
    Approved Symbol:
    LAMA3
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 30
    Human (de-) phosphorylation sites: 30; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Epidermolysis bullosa, generalized atrophic benign(Pd);
  • Epidermolysis bullosa, junctional, Herlitz type(Pd);
  • Laryngoonychocutaneous syndrome(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 4 : 0
  • Isoform 3 : 0
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 02883 Entrez Gene ID: 3909 OMIM ID: 600805 Swissprot Accession: B0YJ33; Q6VU67; Q16787;