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Description for Protein LAMA2

laminin, alpha 2
2 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • EGFLAM: Laminin-type epidermal growth factor-like domain
  • LAMB: Laminin B domain
  • CC: Coiled Coil
  • LAMG: Laminin G domain
  • LAMNT: Laminin N-terminal domain (domain VI)
  • EGFL: EGF domain, unclasssified subfamily
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06239
    KEGG - Pathway(s):
    hsa04510; hsa04512; hsa05200; hsa05222; hsa05410; hsa05412; hsa05414; hsa05416
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Laminin alpha 2 subunit isoform a precursor; Laminin alpha 2 subunit isoform b precursor; Merosin Laminin 2 heavy chain; Laminin M; LAMM; Laminin M chain; Merosin heavy chain
    Approved Symbol:
    LAMA2
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 8
    Human (de-) phosphorylation sites: 8; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Muscular dystrophy, congenital merosin-deficient(Pd);
  • Muscular dystrophy, congenital, due to partial lama2 deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01125 Entrez Gene ID: 3908 OMIM ID: 156225 Swissprot Accession: P24043; Q59H37;