Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein KRT16

keratin 16
2 total interacting proteins;
Icon Book Platelet Evidence (proteome studies/others : 2/0)
(membrane: 1; secretome: 1)
Summary:
The protein encoded by this gene is a member of the keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Most of the type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains and are clustered in a region of chromosome 17q12-q21. This keratin has been coexpressed with keratin 14 in a number of epithelial tissues, including esophagus, tongue, and hair follicles. Mutations in this gene are associated with type 1 pachyonychia congenita, non-epidermolytic palmoplantar keratoderma and unilateral palmoplantar verrucous nevus. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07604
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Keratin type I cytoskeletal 16; Cytokeratin 16; K16; CK 16; KRT16A; NEPPK; K1CP
    Approved Symbol:
    KRT16
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 6
    Human (de-) phosphorylation sites: 6; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Nonepidermolytic palmoplantar keratoderma(Pd);
  • Pachyonychia congenita tarda, type 1(Pd);
  • Pachyonychia congenita, type 1(Pd);
  • Unilateral palmoplantar verrucous nevus, somatic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01018 Entrez Gene ID: 3868 OMIM ID: 148067 Swissprot Accession: P08779;