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Description for Protein KRT14

keratin 14
6 total interacting proteins; 4 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 3/0)
(alpha granules: 1; membrane: 1; secretome: 1)
Summary:
This gene encodes a member of the keratin family, the most diverse group of intermediate filaments. This gene product, a type I keratin, is usually found as a heterotetramer with two keratin 5 molecules, a type II keratin. Together they form the cytoskeleton of epithelial cells. Mutations in the genes for these keratins are associated with epidermolysis bullosa simplex. At least one pseudogene has been identified at 17p12-p11. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07604
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Keratin type I cytoskeletal 14; Cytokeratin 14; K14; CK 14
    Approved Symbol:
    KRT14
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 7
    Human (de-) phosphorylation sites: 7; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Dermatopathia pigmentosa reticularis(Pd);
  • Epidermolysis bullosa simplex, Dowling-Meara type(Pd);
  • Epidermolysis bullosa simplex, Koebner type(Pd);
  • Epidermolysis bullosa simplex, recessive(Pd);
  • Epidermolysis bullosa simplex, Weber-Cockayne type(Pd);
  • Naegeli-franceschetti-jadassohn syndrome(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01017 Entrez Gene ID: 3861 OMIM ID: 148066 Swissprot Accession: P02533;