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Description for Protein KRT5

keratin 5
11 total interacting proteins; 7 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 4/0)
(alpha granules: 1; membrane: 1; platelet: 1; secretome: 1)
Summary:
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the basal layer of the epidermis with family member KRT14. Mutations in these genes have been associated with a complex of diseases termed epidermolysis bullosa simplex. The type II cytokeratins are clustered in a region of chromosome 12q12-q13. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • CC: Coiled Coil
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07605
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    K5; Keratin type II cytoskeletal 5; Cytokeratin 5; CK 5; 58 kDa cytokeratin
    Approved Symbol:
    KRT5
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

  • Dowling-Degos disease(Pd);
  • Epidermolysis bullosa simplex with migratory circinate erythema(Pd);
  • Epidermolysis bullosa simplex with mottled pigmentation(Pd);
  • Epidermolysis bullosa simplex, Dowling-Meara type(Pd);
  • Epidermolysis bullosa simplex, Dowling-Meara type, with severe palmoplantar keratoderma(Pd);
  • Epidermolysis bullosa simplex, Koebner type(Pd);
  • Epidermolysis bullosa simplex, Koebner type, with severe palmoplantar keratosis(Pd);
  • Epidermolysis bullosa simplex, Weber-Cockayne type(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01010 Entrez Gene ID: 3852 OMIM ID: 148040 Swissprot Accession: P13647;