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Description for Protein KRAS

v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
17 total interacting proteins; 12 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 2/1)
(membrane: 1; platelet: 4; undefined: 1)
Summary:
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • RAS: Ras subfamily of RAS small GTPases
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K07827
    KEGG - Pathway(s):
    hsa04010; hsa04012; hsa04062; hsa04320; hsa04360; hsa04370; hsa04530; hsa04540; hsa04650; hsa04660; hsa04662; hsa04664; hsa04720; hsa04722; hsa04730; hsa04810; hsa04910; hsa04912; hsa04914; hsa04916; hsa04960; hsa05200; hsa05210; hsa05211; hsa05212; hsa05213; hsa05214; hsa05215; hsa05216; hsa05218; hsa05219; hsa05220; hsa05221; hsa05223
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    K-RAS4A; K-RAS4B; RASK2; Oncogene KRAS2; Oncogene KRAS1; KRAS1P; KI RAS; C K RAS; K RAS2A; K RAS2B; c K ras protein; K ras p21 protein; c Kirsten ras protein; PR310 c K ras oncogene; Transforming protein p21; Cellular c Ki ras2 proto oncogene; Calu-1; RASK1; c-K-ras2 protein isoform a; c-K-ras2 protein isoform b
    Approved Symbol:
    KRAS
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 4
    Human (de-) phosphorylation sites: 4; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • FARNESYL(db);
  • FARNESYL DIPHOSPHATE(db);
  • [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID(db)

    Associated Genetic Diseases:

  • Bladder cancer, transitional cell, somatic(Pd);
  • Breast adenocarcinoma, somatic(Pd);
  • Cardiofaciocutaneous syndrome(Pd);
  • Costello syndrome(Pd);
  • Gastric cancer, somatic(Pd);
  • Leukemia, acute myelogenous(Pd);
  • Lung cancer, somatic(Pd);
  • Lung cancer, squamous cell, somatic(Pd);
  • Noonan syndrome 3(Pd);
  • Pancreatic carcinoma, somatic(Pd);
  • Pilocytic astrocytoma, somatic(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 0
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01817 Entrez Gene ID: 3845 OMIM ID: 190070 Swissprot Accession: P01116;