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Description for Protein KPNB1

karyopherin (importin) beta 1
58 total interacting proteins; 26 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 9/0)
(alpha granules: 1; membrane: 1; microparticles: 1; platelet: 5; secretome: 1)
Summary:
Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • ARM: Armadillo/beta-catenin-like repeats
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    None Available
    KEGG - Pathway(s):
    None Available
    Nomenclature / Alternative Names:
    Karyopherin beta 1 subunit; Importin beta 1 subunit; Importin beta 1; Nuclear factor P97; Importin 90; NTF97; IMB1; MGC2155; MGC2156; MGC2157; Impnb
    Approved Symbol:
    KPNB1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 9
    Human (de-) phosphorylation sites: 9; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 04114 Entrez Gene ID: 3837 OMIM ID: 602738 Swissprot Accession: Q14974;