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Description for Protein ARG1

arginase, liver
5 total interacting proteins; 2 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exist (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type I isoform encoded by this gene, is a cytosolic enzyme and expressed predominantly in the liver as a component of the urea cycle. Inherited deficiency of this enzyme results in argininemia, an autosomal recessive disorder characterized by hyperammonemia. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
None Available

Gene Ontology:
Gene Ontology Annotations

KEGG - Enzyme ID(s):
3.5.3.1
KEGG - Orthology:
K01476
KEGG - Pathway(s):
hsa00330; hsa01100
(The yellow boxes represents platelet proteins)
Nomenclature / Alternative Names:
Arginine amidinase; Canavanase; Arginase, type I; A-I
Approved Symbol:
ARG1
(De-) Phosphorylations:
Total (de-) phosphorylation sites: 2
Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites

Phosphorylation Targets:
Total phosphorylation targets: 0
Human phosphorylation targets: 0;Predicted platelet targets: 0
Protein Characteristics:
Isoform-specific Information
Icon DrugsAssociated Drugs (DrugBank Accession):

  • 2(S)-Amino-6-Boronohexanoic Acid(db);
  • DEHYDRO-2(S)-AMINO-6-BORONOHEXANOIC ACID(db);
  • Descarboxy-nor-N(Omega)-Hydroxy-L-Arginine(db);
  • Dinor-N(Omega)-Hydroxy-L-Arginine(db);
  • L-Ornithine(db);
  • N-Omega-Hydroxy-L-Arginine(db);
  • Nor-N-Omega-Hydroxy-L-Arginine(db);
  • S,S-(2-Hydroxyethyl)Thiocysteine(db);
  • S-2-(Boronoethyl)-L-Cysteine(db);
  • S-propylamine-L-cysteine(db);
  • S-{2-[Amino(Dihydroxy)-Lambda~4~-Sulfanyl]Ethyl}-D-Cysteine(db);
  • Urea(db)


    Associated Genetic Diseases:

  • Argininemia(Pd)
  • Predicted Transmembrane Domains:
  • Isoform 1 : 0
  • Additional Identifiers:

    HPRD: 01947 Entrez Gene ID: 383 OMIM ID: 608313 Swissprot Accession: P05089