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Description for Protein KLRC1

killer cell lectin-like receptor subfamily C, member 1
4 total interacting proteins; 3 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • LECTIN_C: C-type lectin (CTL) or carbohydrate-recognition domain (CRD)
  • TM: Transmembrane domain
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    None Available
    KEGG - Orthology:
    K06541
    KEGG - Pathway(s):
    hsa04612; hsa04650; hsa05332
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    NK cell receptor A; C-lectin type II protein; Natural killer group protein 2; NKG2-1/B activating NK receptor; CD159A; MGC13374; MGC59791; NKG2-A/NKG2-B type II integral membrane protein; Natural killer P cell surface receptor; Natural killer cell lectin; NKG2; NKG2A; NKG2-A; NKG2-B
    Approved Symbol:
    KLRC1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

    None Available

    Associated Genetic Diseases:

    None Available
    		Predicted Transmembrane Domains:
  • Isoform 4 : 1
  • Isoform 3 : 1
  • Isoform 2 : 1
  • Isoform 1 : 1
    • Additional Identifiers:

    HPRD: 01192 Entrez Gene ID: 3821 OMIM ID: 161555 Swissprot Accession: P26715;