Search

Search for a specific protein in the Platelet Interactome


(Example: vasp)

 

Advanced Search

Get detailed protein information focusing on various characteristics and extract interaction networks

 

Legend

 

About

Go Back

Description for Protein KIT

v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
59 total interacting proteins; 33 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 0/0)
(Not detected in platelets)
Summary:
This gene encodes the human homolog of the proto-oncogene c-kit. C-kit was first identified as the cellular homolog of the feline sarcoma viral oncogene v-kit. This protein is a type 3 transmembrane receptor for MGF (mast cell growth factor, also known as stem cell factor). Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous lukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
  • IGC2: Immunoglobulin C-2 Type
  • Ig_LIKE: Immunoglobulin like
  • TM: Transmembrane domain
  • Tyr_Kinase: tyrosine kinase domain
  • IG: Immunoglobulin
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.7.10.1
    KEGG - Orthology:
    K05091
    KEGG - Pathway(s):
    hsa04060; hsa04144; hsa04640; hsa04916; hsa05200; hsa05221
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    KIT oncogene Mast cell growth factor receptor; Stem cell factor receptor; c-kit; CD117 antigen; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog isoform 1 precursor; v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog isoform 2 precursor
    Approved Symbol:
    KIT
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 36
    Human (de-) phosphorylation sites: 36; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 4
    Human phosphorylation targets: 3; Predicted platelet targets: 1
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Adenosine-5'-Diphosphate(db);
  • Dasatinib(db);
  • Imatinib(db);
  • N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carboxamide(db);
  • Nilotinib(db);
  • Phosphonotyrosine(db);
  • Sorafenib(db);
  • Sti-571(db);
  • Sunitinib(db)

    Associated Genetic Diseases:

  • Gastrointestinal stromal tumor, familial(Pd);
  • Gastrointestinal stromal tumor, somatic(Pd);
  • Germ cell tumor(Pd);
  • Leukemia, acute myeloid(Pd);
  • Mast cell disease, systemic(Pd);
  • Mast cell leukemia(Pd);
  • Mastocytosis, sporadic, childhood-onset(Pd);
  • Piebaldism(Pd);
  • Piebaldism with sensorineural deafness(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 2 : 2
  • Isoform 1 : 2
    • Additional Identifiers:

    HPRD: 01287 Entrez Gene ID: 3815 OMIM ID: 164920 Swissprot Accession: P10721; Q6IQ28;