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Description for Protein ACAT1

acetyl-CoA acetyltransferase 1
1 total interacting proteins; 1 platelet interacting proteins
Icon Book Platelet Evidence (proteome studies/others : 1/0)
(platelet: 1)
Summary:
This gene encodes a mitochondrially localized enzyme that catalyzes the reversible formation of acetoacetyl-CoA from two molecules of acetyl-CoA. Defects in this gene are associated with 3-ketothiolase deficiency, an inborn error of isoleucine catabolism characterized by urinary excretion of 2-methyl-3-hydroxybutyric acid, 2-methylacetoacetic acid, tiglylglycine, and butanone. [provided by RefSeq] (PubMed Links)
Domains and Motifs:
  • SP: Signal Peptide
    • Gene Ontology:
    Gene Ontology Annotations
    KEGG - Enzyme ID(s):
    2.3.1.9
    KEGG - Orthology:
    K00626
    KEGG - Pathway(s):
    hsa00071; hsa00072; hsa00280; hsa00310; hsa00380; hsa00620; hsa00640; hsa00650; hsa00900; hsa01100
    (The yellow boxes represents platelet proteins)
    Nomenclature / Alternative Names:
    Acetyl-CoA acetyltransferase, mitochondrial; Acetyl-CoA thiolase; T2; ACAT; MAT
    Approved Symbol:
    ACAT1
    (De-) Phosphorylations:
    Total (de-) phosphorylation sites: 2
    Human (de-) phosphorylation sites: 2; No platelet phosphorylation sites
    Phosphorylation Targets:
    Total phosphorylation targets: 0
    Human phosphorylation targets: 0;Predicted platelet targets: 0
    		Protein Characteristics:
    Isoform-specific Information
    Icon DrugsAssociated Drugs (DrugBank Accession):

  • Sulfasalazine(db)

    Associated Genetic Diseases:

  • 3-@ketothiolase deficiency(Pd)
    		• Predicted Transmembrane Domains:
  • Isoform 1 : 0
    • Additional Identifiers:

    HPRD: 01946 Entrez Gene ID: 38 OMIM ID: 607809 Swissprot Accession: P24752;